Ximing Xu

Time:2015-12-24 Onclick:

Professor, Department of Pharmaceutics, Jiangsu University

Dean, School of Pharmacy.

Director, Center for Nano Drug/Gene Delivery and Tissue Engineering.

Vice-chairman, Pharmaceutical Science Committee of Jiangsu Pharmaceutical Association

Education and Experience

2006.1-2006.7 Research Fellow, Lab of Gene Transfer and Tissue Repair, Harvard Medical School

2004.3-2005.12 Visiting Associate Professor /Research Fellow, Harvard Medical School. Tissue Engineering Laboratories, VA Boston Healthcare System.

1996.9-1999.6 Ph.D., Pharmaceutics/Drug Delivery, China Pharmaceutical University

1993.9-1996.6 Master in Medicine, Peking University (original Beijing Medical University)

1983.9-1987.6 B.Sc., Chemistry and Chemical Engineering, Soochow University

Research Interest

Natural biomaterials for nano gene transfer and stem cell based Tissue Engineering

Controlled release preparations and Pharmacokinetic evaluation of poorly soluble drugs

High screening and formulation development of active components from Traditional Chinese Medicine.

Ongoing Projects

Direct reprogramming with CDs modified self-assembly nanoparticles.National Natural Science Foundation of China (PI, 2015-2018, No. 81473172, one million RMB )

iPS generation via micro-RNA non viral delivery strategy.National Natural Science Foundation of China (PI, 2013-2016, No. 81273470, one million RMB); Doctoral Fund of Ministry of Education of China (20123227110009)

Non viral nanoparticle gene delivery systems for the generation of induced pluripotent stem Cells. National Natural Science Foundation of China(PI, No. 81072586); Special funds for 333 and 331 project(PI, No. BRA2013198)

Lipid rafts chromatography for the highly screening anti-tumor drugs from Traditional Chinese Medicine, National Natural Science Foundation of China(No. 30973677)

Pharmaceutical biotechnology and translational medicine.A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions. (Project leader, 2014-2017, 40 million RMB)

Screening of new active components fromedible fungi.National "Twelfth Five-Year" Plan for Science & Technology Support (2013BAD16B07-1); Special funds for Industry-University-Research Institution Cooperation (PI, JHB2012-37, GY2012049).

Poorly soluble drug formulations for controlled release(PI, fund from Yangzi River Pharmaceutical Group, one of the most famous pharmaceutical company in China)

High efficiency hepatic protective preparations from Traditional Chinese Medicine(PI, funding from the Center of Zhendong Ecological Biotech Development )

Selected Publications (*corresponding author)

2014

[1] Yuan Zhu, Wei Peng, Jiajia Zhang, Miaomiao Wang, Caleb Kesse Firempong, Chunlai Feng, Hongfei Liu,Ximing Xu*, Jiangnan Yu*. Enhanced oral bioavailability of capsaicin in mixed polymeric micelles: Preparation, in vitro and in vivo evaluation.Journal of Functional Foods, 2014, 8: 358-366.

[2] Shanshan Tong, Hui Zhong, Chengxue Yi, Xia Cao, Caleb Kesse Firempong, Qianfeng Zheng, Yingshu Feng, Jiangnan Yu*,Ximing Xu*. Simultaneous HPLC determination of ergosterol and 22,23-dihydroergosterol in Flammulina velutipes sterol-loaded microemulsion.Biomed Chromatogr, 2014, 28(2): 247-254.

[3] Shanshan Tong, Min Fu, Xia Cao, Caleb Kesse Firempong, Chengxue Yi, Qianfeng Zhen, Hui Zhong, Jiangnan Yu,Ximing Xu*. Lipid Raft Stationary Phase Chromatography for Screening Anti-tumor Components from Galla chinensis.Chromatographia, 2014, 77(5-6): 419-429.

[4]Li Yue, Wang Xiang-Yu, Zhang Rui-Zhuo, Zhang Xiao-Yun, Liu Wei,Xu Xi-Ming, Zhang Ye-Wang. Molecular Imprinting and Immobilization of Cellulase Onto Magnetic Fe3O4@SiO2 Nanoparticles.Journal of Nanoscience and Nanotechnology.2014, 14(4):2931-2936.

[5] Shanshan Tong, Chaonan Sun, Xia Cao, Qianfeng Zheng, Huiyun Zhang, Caleb Kesse Firempong, Yingshu Feng, Yan Yang, Jiangnan Yu,Ximing Xu*. Development and thermodynamic evaluation of novel lipid raft stationary phase chromatography for screening potential antitumor agents.Biomedical Chromatography, 2014. Published online. DOI: 10.1002/bmc.3189.

[6] Yuan Zhu, Jiajia Zhang, Min Fu, Jin Zeng, E. Omari-Siaw,Xi-ming Xu*. Calcium carbonate nanoparticles templated by mixed polymeric micelles: characterization, in vitro drug release and oral bioavailability in Beagle dogs.Latin American Journal of Pharmacy, 2014, 33(7): 1106-1113.

[7] Yuan Zhu, Miaomiao Wang, Jiajia Zhang, Wei Peng, Caleb Kesse Firempong, Wenwen Deng, Qilong Wang, Shicheng Wang, Feng Shi, Jiangnan Yu,Ximing Xu*, Weiming Zhang*. Improved oral bioavailability of capsaicin via liposomal nanoformulation: preparation, in vitro drug release and pharmacokinetics in rats.Archives of Pharmacal. Reseach, 2014, Published online. DOI: 10.1007/s12272-014-0481-7

[8]Liu Wei, Zhou Fang, Zhang Xiao-Yun, Li Yue, Wang Xiang-Yu,Xu Xi-Ming,Zhang Ye-Wang. Preparation of Magnetic Fe3O4@SiO2 Nanoparticles for Immobilization of Lipase.Journal of Nanoscience and Nanotechnology. 2014, 14(4):3068-3072.

[9] Wei Peng, Xinyi Jiang, Yuan Zhu, E. Omari-Siaw, Wenwen Deng, Jiangnan, Yu, Ximing Xu*, Weiming Zhang. Preparation and quality evaluation of MPEG-PCL nanoparticles as a carrier for oral delivery of capsaicin.Acta Pharmacologica Sinica, 2014, Accepted.

[10] Ying Xu, Xuefeng Jin, Qineng Ping, Hongfei Liu, Mei Chen,Ximing Xu.Recent development of natural and reconstituted lipoprotein based nano drug delivery vehicles.Acta Pharmaceutica Sinica, 2014, (1): 23-29.

[11] Yuan Zhu, Jiajia Zhang, Qianfeng Zheng, Miaomiao Wang, Wenwen Deng, Li Qiang, Caleb Kesse Firempong, Shengli Wang, Shanshan Tong,Ximing Xu*, Jiangnan Yu*. In vitro and in vivo evaluation of capsaicin-loaded microemulsion for enhanced oral bioavailability. Submitted.

[12] Jiajia Zhang, Caleb Kesse Firempong, Yuan Zhu, Xia Cao, Xiaolei Shi, Guanghui Zhou, Jiangnan Yu*,Ximing Xu*, Weiming Zhang*. Self-microemulsifying drug delivery system for improved oral delivery of limonene: preparation, characterization, in vitro and in vivo evaluation. Submitted.

[13]Wenwen Deng, Xia Cao, Jiangnan Yu, Jingjing Chen, Yan Wang, Qingtong Yu, Zhijian Zhang, Genbao Shao, Jie Zhou, Xiangdong Gao, andXiming Xu*. Generation of human induced pluripotent stem cells via self-assembly cationized Pleurotus eryngii polysaccharide nanoparticles incorporating Oct4, Sox2 and MiR 302-367. Submitted.

[14]Wenwen Deng, Xia Cao, Jiangnan Yu, Qingtong Yu, Yan Wang, Jingjing Chen, Zhijian Zhang, Jie Zhou, Jiabo Hu, Xiangdong Gao, andXiming Xu*. Incorporating pOSKM-cationized polysaccharide-calcium phosphate hybrid nanoparticles into 3D scaffolds for direct generation of pluripotent embryoid body-like 3D spheres. Submitted.

[15]Rui Qu, Chaonan Sun, Caleb Kesse Firempong, Chaoqun Xi, Xia Cao, Wenwen Deng, Zhijian Zhang, Shanshan Tong, Huiyun Zhang, Yan Wang, Weiting Zhou, Huan Yang, Jiangnan Yu, andXiming Xu*. Multitarget Lipid Raft-Coated Silica Beads with Quantum dots imaging: an on-line Platform for Isolating Antitumor Natural Compounds with Multiple Targets. Submitted.

2013

[1] Xia Cao, Wenwen Deng, Rui Qu, Yan Yang, Jun Li, Yue Cao,Ximing Xu*, Jiangnan Yu. Non-viral co-delivery of the four Yamanaka factors for generation of human induced pluripotent stem cells via calcium phosphate nanocomposite particles.Advanced Functional Materials, 2013, 23(43): 5403-5411.

[2]Xinyi Jiang,Xianyi Sha,Hongliang Xin,Ximing Xu,Jijin Gu,Weiyi Xia,Shuo Chen,Yike Xie,Liangcen Chen,Yanzuo Chen,Xiaoling Fang. Integrin-facilitated transcytosis for enhanced penetration of advanced gliomas by poly(trimethylene carbonate)-based nanoparticles encapsulating paclitaxel.Biomaterials, 2013, 34 : 2969-2979.

[3]Xinyi Jiang,Hongliang Xin,Jijin Gu,Ximing Xu,Weiyi Xia,Shuo Chen,Yike Xie,Liangcen Chen,Yanzuo Chen,Xianyi Sha,Xiaoling Fang. Solid tumor penetration by integrin-mediated pegylated poly(trimethylene carbonate) nanoparticles loaded with paclitaxel Biomaterials.Biomaterials, 2013, 34: 1739-1746.

[4] Wenwen Deng, Min Fu, Yue Cao, Xia Cao, Miao Wang, Yan Yang, Rui Qu, Jun Li,Ximing Xu*, Jiangnan Yu. Angelica sinensis polysaccharide nanoparticles as novel non-viral carriers for gene delivery to mesenchymal stem cells.Nanomedicine: Nanotechnology, Biology, and Medicine, 2013, 9: 1181-1191.

[5] Chengxue Yi, Chaonan Sun, Shanshan Tong, Xia Cao, Yingshu Feng, Caleb Kesse Firempong, Xinyi Jiang,Ximing Xu*,, Jiangnan Yu, Cytotoxic effect of novel Flammulina velutipes sterols and its oral bioavailability via mixed micellar nanoformulation.International Journal of Pharmaceutics, 2013, 448: 44– 50.

[6] Xia Cao, Wenwen Deng, Min Fu, Yuan Zhu, Hongfei Liu, Li Wang, Jin Zeng, Yawei Wei,XimingXu, Jiangnan Yu. Seventy-two-hour release formulation of the poorly soluble drug silybin based on porous silica nanoparticles: In vitro release kinetics and in vitro/in vivo correlations in beagle dogs.Eur J Pharm Sci, 2013, 48:64-71

[7] Chengxue Yi, Min Fu, Xia Cao, Shanshan Tong, Qianfeng Zheng, Caleb Kesse Firempong, Xinyi Jiang,Ximing Xu, Jiangnan Yu. Enhanced oral bioavailability and tissue distribution of a new potential anticancer agent, Flammulina velutipes sterols, through liposomal encapsulation.Journal of Agricultural and Food Chemistry, 2013, 61: 5961-5971.

[8]Li Hui, Dong Wen-feng, Zhou Jian-yuan,Xu Xi-ming,Li Feng-qian. Triggering effect of N-acetylglucosamine on retarded drug release from a lectin-anchored chitosan nanoparticles-in-microparticles system.International Journal of Pharmaceutics.2013, 449(1-2):37-43.

[9]Mei Lin, Wang Liang, Li Qianqian, Yu jiangnan,Xu Ximing*.Comparison of acid degumming and enzymatic degumming process for Silybum marianum seed oil. Journal of the Science of Food and Agriculture.2013 93(11):2822-2828.

[10]Wang Li, Wang Yan-song, Chen Rong-ying, Feng Chun-lai, Wang Hao, Zhu Xi-wen, Yu Jiang-nan,Xu Xi-ming*.PLGA microspheres as a delivery vehicle for sustained release of tetracycline: biodistribution in mice after subcutaneous administration.Journal of Drug Delivery Science and Technology. 2013, 23(6):547-553.

[11] Linfeng Guo, Shanshan Tong, Jiangnan Yu,Ximing Xu. Advance in studies on anti-tumor mechanism of matrine.China Journal of Chinese Materia Medica, 2013, (20): 3409-3412.

[12] Min Fu;Ximing Xu, Jiangnan Yu .Research Progress on Preparation of Porous PLGA Scaffold and Its Application in Gene Delivery System.Progress in Pharmaceutical Science, 2013, (8): 376-382.

[13] Huiyun Zhang, Qinghua He, Shanshan Tong, Jinagnan Yu,Ximing Xu.Advances in Research on Active Constituents from Periplocae Cortex and Their Pharmacological Activities.Progress in Pharmaceutical Scie, nce, 2013, (9): 449-453.

2012

[1] Xia Cao, Wenwen Deng, Yuan Wei, Yan Yang, Weiyan Su, Yawei Wei, Jiangnan Yu, andXiming Xu*. Incorporating pTGF-β1/calcium phosphate nanoparticles with fibronectin into 3-dimensional collagen/chitosan scaffolds: efficient, sustained gene delivery to stem cells and chondrogenic differentiation.Eur Cells Mater2012, 23:81-93.

[2] Wen-Wen Deng, Miao Wang, Xia Cao, Yan Yang, Wei-Yan Su, Ya-Wei Wei, Zhen Ou-Yang, Jiang-Nan Yu, andXi-Ming Xu*. Efficient Gene Delivery to Mesenchymal Stem Cells by Ethylenediamine-modified Polysaccharide from Mulberry Leaves.Small2012, 8(3):441-451.

[3] Xia Cao, Wen-wen Deng, Min Fu, Shan-shan Tong, Hong-fei Liu, Ya-wei Wei, Ying Xu, Jin Zeng, Jiang-nan Yu andXi-ming Xu*. In vitro controlled release and in vitro-in vivo correlation for silybin meglumine incorporated in holey pet ball-like silica nanoparticles.Int J Nanomed2012, 7:753-762.

[4] Wenwen Deng, Xia Cao, Miao Wang, Rui Qu, Weiyan Su, Yan Yang, Yawei Wei, Jiangnan Yu, andXiming Xu*. Delivery of a Transforming Growth Factor Beta-1 Plasmid to Mesenchymal Stem Cells via Cationized Pleurotus eryngii Polysaccharide Nanoparticles.Int J Nanomed2012, 7:1297-1311.

[5] Xia Cao, Min Fu, Liang Wang, Hongfei Liu, Wenwen Deng, Rui Qu, Weiyan Su, Yawei Wei, Jiangnan Yu,Ximing Xu*.Oral Bioavailability of Silymarin Formulated as a Novel 3-day Delivery System Based on Porous Silica Nanoparticles.Acta Biomater2012, 8:2104-2112.

[6] Yi C, Zhong H, Tong S, Cao X, Firempong CK, Liu H, Fu M, Yang Y, Feng Y, Zhang H,Xu X*,Yu J. Enhanced oral bioavailability of a sterol-loaded microemulsion formulation of Flammulina velutipes, a potential antitumor drug.Int J Nanomed. 2012, 7:5067-78.

[7] Lina Ju, Shanshan Tong, Liang Wang, Jiangnan Yu,Ximing Xu.Advance in hepatic protective formulations of traditional Chinese medicine and their quality control methods.China Journal of Chinese Materia Medica, 2012, (20): 3007-3011.

[8] Qian Deng, Shanshan Tong, Lixia Ding,Ximing Xu, Jiangnan Yu. Research progress in the analysis methods of functional components in pine pollen and its biological activities.Chinese Journal of Pharmaceutical Analysis, 2012, (1): 173-178.

[9] Hui Li, Juan Bi,Ximing Xu, Fengqian Li. Wheat germ agglutinin anchored chitosan nanoparticles and its conjugation with N-acetylglucosamine.Acta Pharmaceutica Sinica, 2012, (1): 131-134.

[10] Shanshan Tong, Yan Yang, Lixia Ding, Longfeng Xu,Ximing Xu, Jiangnan Yu. HPLC simultaneous determination of theophylline and chlorphenamine maleate in Shunqi Huatan tablets and Granules.Chinese Journal of Pharmaceutical Analysis, 2012, (4): 583-586.

[11] Nannan Ding, Shanshan Tong, Lixia Ding,Ximing Xu, Jiangnan Yu Research progress in analysis methods and pharmacological effects of berberine.Chinese Journal of Pharmaceutical Analysis, 2012, (7): 1296-1300.

[12] Sheng Shen, Hongfei Liu,Ximing Xu, Jiangnan Yu. Research Progress of Drugs for Diabetic Complication Treatment.Chinese Pharmaceutical Affairs, 2012, (8): 906-910.

Before 2012

[1] Xia Cao, Wenwen Deng, Yuan Wei, Weiyan Su, Yan Yang, Yawei Wei, Jiangnan Yu, andXimingXu*. Encapsulation of Plasmid DNA in Calcium Phosphate Nanoparticles: Stem Cell Uptake and Gene Transfer Efficiency.Int J Nanomed, 2011, 6:3335-3349.

[2] Miao Wang, Wenwen Deng, Min Fu, Xia Cao, Yan Yang, Weiyan Su, Jiangnan Yu,Ximing Xu*. Efficient gene transfer into rat mesenchymal stem cells with cationized Lycium barbarum polysaccharides nanoparticles.Carbohydrate Polymers, 2011, 86:1509–1518.

[3] Shanshan Tong, Chang Chu, Yuan Wei, Li Wang, Xizhe Gao,Ximing Xu*, Jiangnan Yu. Preparation and effects of 2,3-dehydrosilymarin, a promising and potent antioxidant and free radical scavenger.Journal of Pharmacy and Pharmacology, 2011, 63(2): 238-44.

[4] Chang CHU, Shan-shan TONG, Ying XU, Min FU, Yan-ru GE, Jiang-nan Yu,Xi-ming XU*. Proliposomes for the oral delivery of dehydrosilymarin: preparation and evaluation in vitro and in vivo.Acta Pharmaco Sin, 2011, 32: 973-980

[5]Xi-ming XU, Yan-song WANG, Rong-ying CHEN, Chun-lai FENG, Feng YAO, Shan-shan TONG, Li WANG, Fumiyoshi YAMASHITA, Jiang-nan YU.Formulation and pharmacokinetic evaluation of tetracycline-loaded solid lipid nanoparticles (Tet-SLN) for subcutaneous injection in mice.Chem Pharm Bull, 2011, 59(2): 260-265.

[6] Huiyun Zhang, Qinghua He, Shanshan Tong, Jinagnan Yu,Ximing Xu*. Advances in Research on Active Constituents from Periplocae Cortex and Their Pharmacological Activities.Progress in Pharmaceutical Science, 2011, (1): 85-88.

[7] Li Dong,Ximing Xu, Jiangnan Yu. A research overview of medicine ointment.China Pharmacist, 2011, (1): 129-132.

[8] Feng Yao, Nao Murakami, Oliver Bleiziffer, Pengwei Zhang, Natali V. Akhrameyeva,Ximing Xu*, Richard Brans. Development of a Regulatable Oncolytic Herpes Simplex Virus Type 1 Recombinant Virus for Tumor Therapy.Journal of Virology2010, 84(16): 8163-8171.

[9] Ye-Wang Zhang, Rui-Jiang Liu,Xi-Ming Xu*. One-pot, two-step enzymatic synthesis of amoxicillin by complexing with Zn2+.Applied Microbiology and Biotechnology, 2010, 88(1): 49-55.

[10] Jiang-nan YU, Yuan ZHU, Li WANG, Min PENG, Shan-shan TONG, Xia CAO, Hui QIU,Xi-ming XU. Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles.Acta Pharmacologica Sinica, 2010, 31(6): 759-764.

[11] Yuan Zhu, Jiangnan Yu, Shanshan Tong, Li Wang, Min Peng, Xia Cao,Ximing Xu. Preparation and In Vitro Evaluation of Povidone-Sodium Cholate-Phospholipid Mixed Micelles for the Solubilization of Poorly Soluble Drugs.Archives of Pharmacal Research, 2010, 33(6): 911-917.

[12] Shu-Guang Fang; Tan Qiang; Rui-Jiang Liuad;Xi-Ming Xu; Ye-Wang Zhang. Enhanced Production of 6-Aminopenicillanic Acid in Aqueous Methyl Isobutyl Ketone System with Immobilized Penicillin G Acylase.Prep Biochem Biotechnol, 2010, 40(1): 38-45.

[13] Weiyan Su,Ximing Xu, Jiangnan Yu. Research Progress of drug metabolism for primary cultured rat hepatocytes.Pharmaceutical Biotechnology, 2010, (6): 534-537.

[14] Yewang Zhang, Ruijiang Liu, Chongwei Wen,Ximing Xu*. Progress in optimization for synthesis of β-lactam antibiotics with penicillin acylase.Chinese Journal of Antibiotics, 2010, (10): 721-726.

[15] Yanhong Chao,Ximing Xu, Jiangnan Yu. Research Progress on the New Dosage Forms and Quality Control Methods of Breviscapine.Chinese Pharmaceutical Affairs, 2010, (7): 711-715.

[16] Shanshan Tong, Xubo Wang, Yuping Shen, Yan Ding, Jiangnan Yu,Ximing Xu*. Study on body distribution and hepatic targeting tendency of galactosyl adriamycin bovine serum albumin nanoparticles in mice by radioisotope tracing.Chinese Journal of Pharmaceutical Analysis, 2010, (1): 77-81.

[17] Zheming Lu, Richard Brans, Natali V. Akhrameyeva, Nao Murakami,Ximing Xu, Feng Yao. High-level expression of glycoprotein D by a dominant-negative HSV-1 virus augments its efficacy as a vaccine against HSV-1iInfection.J Invest Derma2009; 129(5): 1174-1184.

[18]Ximing Xu, Ramille M. Capito, Myron Spector. Plasmid size influences chitosan nanoparticle mediated gene transfer to chondrocytes.J Biomed Mat Res A, 2008, 84A(4): 1038-1048.

[19]Ximing Xu, Ramille M. Capito, Myron Spector. Delivery of plasmid IGF-1 to chondrocytes via cationized gelatin nanoparticles.Journal of Biomedical Materials Research Part A, 2008, 84A(1): 73-82.

[20] Ye-Wang Zhang, Shu-Lai Liu, Dong-Zhi Wei, Rui-Jiang Liu,Xi-Ming Xu.Kinetically Controlled Synthesis of Cefaclor with Immobilized Penicillin Acylase in the Presence of Organic Cosolvents.Chem Biochem Eng Q, 2008, 22 (3): 349-354.

[21] Shanshan Tong, Xubo Wang, Yan Ding, Jiangnan Yu,Ximing Xu. Pharmacokinetics of Galactosyl Adriamycin BSA Nanoparticles in Mice by RP-HPLC with Fluorescence Detection.Chinese Pharmaceutical Journal, 2009, (24): 1908-1912.

[22] Shanshan Tong, Jiangnan Yu,Ximing Xu, Xiaoyan Liu, Hua Jin, Yaping Xu. Determination of Chlorogenic Acid of Herba Artemisiae sopariae Extracts and Evaluation of Its Antioxidant Activity Using TLC-Bioautography.Chinese Pharmaceutical Journal, 2009, (22): 1738-1741.

[23] Zhen fang Yan,Ximing Xu, Jiangnan Yu. Advances in Research of Targeting Drug Delivery Systems Mediated by Receptors.Pharmaceutical Biotechnology, 2009, (5): 481-485.

[24] Yanyan Wang,Ximing Xu, Jiangnan Yu,. Domestic and Overseas Research and Development of Cataplasm.Chinese Pharmaceutical Affairs, 2009, (6): 603-606.

POSITION AVAILABLE

POSTDOC with background in Molecular Biology, Cell Biology, Clinical Medicine and Pharmaceutical Science and Tissue Engineering

Graduates for Doctor degree in Laboratory Medicine; Master degree in Pharmaceutical Science and Traditional Chinese Medicine

Contact Information

Tel & Fax: 86-511-88791396

Email:xmxu@ujs.edu.cn

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Address:School of Pharmacy,Jiangsu University,Zhenjiang,Jiangsu,P.R.China,Post  Tel:+86-511-85038451-805 Fax:+86-511-85038451-806 E-mail:phar@ujs.edu.cn
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